Age-dependent metabolic and immunosuppressive effects of Tacrolimus

Immunosuppression in elderly recipients has been underappreciated in clinical trials. Here, we assessed age-specific effects of the calcineurin inhibitor Tacrolimus (TAC) in a murine transplant model and assessed its clinical relevance on human T-cells. Old recipient mice exhibited prolonged skin gr...

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Publicat a:Am J Transplant
Autors principals: Krenzien, Felix, Quante, Markus, Heinbokel, Timm, Seyda, Midas, Minami, Koichiro, Uehara, Hirohito, Biefer, Hector Rodriguez Cetina, Schuitenmaker, Jeroen M., Gabardi, Steven, Splith, Katrin, Schmelzle, Moritz, Petrides, Athena K., Azuma, Haruhito, Pratschke, Johann, Li, Xian C., ElKhal, Abdallah, Tullius, Stefan G.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395364/
https://ncbi.nlm.nih.gov/pubmed/27754593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14087
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