Age-dependent metabolic and immunosuppressive effects of Tacrolimus

Immunosuppression in elderly recipients has been underappreciated in clinical trials. Here, we assessed age-specific effects of the calcineurin inhibitor Tacrolimus (TAC) in a murine transplant model and assessed its clinical relevance on human T-cells. Old recipient mice exhibited prolonged skin gr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Am J Transplant
Autori principali: Krenzien, Felix, Quante, Markus, Heinbokel, Timm, Seyda, Midas, Minami, Koichiro, Uehara, Hirohito, Biefer, Hector Rodriguez Cetina, Schuitenmaker, Jeroen M., Gabardi, Steven, Splith, Katrin, Schmelzle, Moritz, Petrides, Athena K., Azuma, Haruhito, Pratschke, Johann, Li, Xian C., ElKhal, Abdallah, Tullius, Stefan G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395364/
https://ncbi.nlm.nih.gov/pubmed/27754593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14087
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi