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Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

Allosteric modulators that are targeting the calcium-sensing receptor (CaSR) hold great therapeutic potential, and elucidating the molecular basis for modulation would thus benefit the development of novel therapeutics. In the present study, we aimed at investigating the mechanism of allosteric modu...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jacobsen, Stine Engesgaard, Gether, Ulrik, Bräuner-Osborne, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394417/
https://ncbi.nlm.nih.gov/pubmed/28417952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46355
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