Pharmacodynamic Model of Parathyroid Hormone Modulation by a Negative Allosteric Modulator of the Calcium-Sensing Receptor

In this study, a pharmacodynamic model is developed, based on calcium–parathyroid hormone (PTH) homeostasis, which describes the concentration–effect relationship of a negative allosteric modulator of the calcium-sensing receptor (CaR) in rats. Plasma concentrations of drug and PTH were determined f...

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Main Authors: Abraham, Anson K., Maurer, Tristan S., Kalgutkar, Amit S., Gao, Xiang, Li, Mei, Healy, David R., Petersen, Donna N., Griffith, David A., Mager, Donald E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085713/
https://ncbi.nlm.nih.gov/pubmed/21437757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9266-9
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