Mutational spectra of aflatoxin B(1) in vivo establish biomarkers of exposure for human hepatocellular carcinoma

Aflatoxin B(1) (AFB(1)) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB(1)-DNA adducts in hepatocytes seeds a population of mutations, mainly G:C→T:A, and viral processes synergize to acc...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chawanthayatham, Supawadee, Valentine, Charles C., Fedeles, Bogdan I., Fox, Edward J., Loeb, Lawrence A., Levine, Stuart S., Slocum, Stephen L., Wogan, Gerald N., Croy, Robert G., Essigmann, John M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393230/
https://ncbi.nlm.nih.gov/pubmed/28351974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700759114
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