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Mutational spectra of aflatoxin B(1) in vivo establish biomarkers of exposure for human hepatocellular carcinoma
Aflatoxin B(1) (AFB(1)) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB(1)-DNA adducts in hepatocytes seeds a population of mutations, mainly G:C→T:A, and viral processes synergize to acc...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5393230/ https://ncbi.nlm.nih.gov/pubmed/28351974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700759114 |
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