Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

The Middle East respiratory syndrome (MERS) emerged in Saudi Arabia in 2012, caused by a zoonotically transmitted coronavirus (CoV). Over 1,900 cases have been reported to date, with ∼36% fatality rate. Lack of autopsies from MERS cases has hindered understanding of MERS-CoV pathogenesis. A small an...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Kun, Wohlford-Lenane, Christine L., Channappanavar, Rudragouda, Park, Jung-Eun, Earnest, James T., Bair, Thomas B., Bates, Amber M., Brogden, Kim A., Flaherty, Heather A., Gallagher, Tom, Meyerholz, David K., Perlman, Stanley, McCray, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393213/
https://ncbi.nlm.nih.gov/pubmed/28348219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619109114
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