Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection

Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe and fatal acute respiratory disease in humans and remains endemic in the Middle East since first being identified in 2012. There are currently no approved vaccines or therapies available for MERS-CoV. In this study, we evaluate...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Li, Kun, Li, Zhuo, Wohlford-Lenane, Christine, Meyerholz, David K., Channappanavar, Rudragouda, An, Dong, Perlman, Stanley, McCray, Paul B., He, Biao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157776/
https://ncbi.nlm.nih.gov/pubmed/32265331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00554-20
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