Intranasal Treatment with Poly(I·C) Protects Aged Mice from Lethal Respiratory Virus Infections

In the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic, no patients under 24 years of age died, while mortality was greater than 50% in those over 65 years. Greater than 90% of all deaths from influenza A virus (IAV) occur in the elderly (>65 years of age). To address...

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Bibliografiske detaljer
Main Authors: Zhao, Jincun, Wohlford-Lenane, Christine, Zhao, Jingxian, Fleming, Erica, Lane, Thomas E., McCray, Paul B., Perlman, Stanley
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486278/
https://ncbi.nlm.nih.gov/pubmed/22915814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01410-12
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