Molecular mechanisms of inhibition on STIM1-Orai1 mediated Ca(2+) entry induced by 2-aminoethoxydiphenyl borate

Store operated Ca(2+) entry (SOCE) mediated by STIM1 and Orai1 is crucial for Ca(2+) signaling and homeostasis in most cell types. 2-aminoethoxydiphenyl borate (2-APB) is a well described SOCE inhibitor but its action remains largely elusive. Here we show that 2-APB does not affect the dimeric state...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Wei, Ming, Zhou, Yandong, Sun, Aomin, Ma, Guolin, He, Lian, Zhou, Lijuan, Zhang, Shuce, Liu, Jin, Zhang, Shenyuan L., Gill, Donald L., Wang, Youjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393042/
https://ncbi.nlm.nih.gov/pubmed/27726010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-016-1880-z
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