Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products

Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elevated concentrations. Red blood cells can synthesize H(2)S but, lacking organelles, cannot dispose of H(2)S via the mitochondrial sulfide oxidation pathway. We have recently shown that at high sulfide concentrations, ferric...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vitvitsky, Victor, Yadav, Pramod K., An, Sojin, Seravalli, Javier, Cho, Uhn-Soo, Banerjee, Ruma
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392699/
https://ncbi.nlm.nih.gov/pubmed/28213526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.774943
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