Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products

Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elevated concentrations. Red blood cells can synthesize H(2)S but, lacking organelles, cannot dispose of H(2)S via the mitochondrial sulfide oxidation pathway. We have recently shown that at high sulfide concentrations, ferric...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Vitvitsky, Victor, Yadav, Pramod K., An, Sojin, Seravalli, Javier, Cho, Uhn-Soo, Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392699/
https://ncbi.nlm.nih.gov/pubmed/28213526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.774943
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