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A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation

Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H(2)S to glutathione persulfide with concomitant reduction of CoQ(10). We report herein that the promiscuous activity of human SQR supported the conversion of CoA to CoA-SSH (CoA-persulfide), a potent inhibitor of butyryl-...

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Bibliografski detalji
Izdano u:Cell Chem Biol
Glavni autori: Landry, Aaron P., Moon, Sojin, Kim, Hanseong, Yadav, Pramod K, Guha, Arkajit, Cho, Uhn-Soo, Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906606/
https://ncbi.nlm.nih.gov/pubmed/31591036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.09.010
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