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DISMANTLING AND REBUILDING THE TRISULFIDE COFACTOR DEMONSTRATES ITS ESSENTIAL ROLE IN HUMAN SULFIDE QUINONE OXIDOREDUCTASE
Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Recent structures of human SQOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration. Here, we assessed the importance of this...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442744/ https://ncbi.nlm.nih.gov/pubmed/32787249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06066 |
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