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DISMANTLING AND REBUILDING THE TRISULFIDE COFACTOR DEMONSTRATES ITS ESSENTIAL ROLE IN HUMAN SULFIDE QUINONE OXIDOREDUCTASE

Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Recent structures of human SQOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration. Here, we assessed the importance of this...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Landry, Aaron P., Moon, Sojin, Bonanata, Jenner, Cho, Uhn Soo, Coitiño, E. Laura, Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442744/
https://ncbi.nlm.nih.gov/pubmed/32787249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06066
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