DISMANTLING AND REBUILDING THE TRISULFIDE COFACTOR DEMONSTRATES ITS ESSENTIAL ROLE IN HUMAN SULFIDE QUINONE OXIDOREDUCTASE

Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Recent structures of human SQOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration. Here, we assessed the importance of this...

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Landry, Aaron P., Moon, Sojin, Bonanata, Jenner, Cho, Uhn Soo, Coitiño, E. Laura, Banerjee, Ruma
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442744/
https://ncbi.nlm.nih.gov/pubmed/32787249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06066
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