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DISMANTLING AND REBUILDING THE TRISULFIDE COFACTOR DEMONSTRATES ITS ESSENTIAL ROLE IN HUMAN SULFIDE QUINONE OXIDOREDUCTASE
Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Recent structures of human SQOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration. Here, we assessed the importance of this...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442744/ https://ncbi.nlm.nih.gov/pubmed/32787249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06066 |
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