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A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation
Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H(2)S to glutathione persulfide with concomitant reduction of CoQ(10). We report herein that the promiscuous activity of human SQR supported the conversion of CoA to CoA-SSH (CoA-persulfide), a potent inhibitor of butyryl-...
Shranjeno v:
| izdano v: | Cell Chem Biol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6906606/ https://ncbi.nlm.nih.gov/pubmed/31591036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.09.010 |
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