A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation

Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H(2)S to glutathione persulfide with concomitant reduction of CoQ(10). We report herein that the promiscuous activity of human SQR supported the conversion of CoA to CoA-SSH (CoA-persulfide), a potent inhibitor of butyryl-...

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Publicado en:Cell Chem Biol
Autores principales: Landry, Aaron P., Moon, Sojin, Kim, Hanseong, Yadav, Pramod K, Guha, Arkajit, Cho, Uhn-Soo, Banerjee, Ruma
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906606/
https://ncbi.nlm.nih.gov/pubmed/31591036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.09.010
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