Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products

Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elevated concentrations. Red blood cells can synthesize H(2)S but, lacking organelles, cannot dispose of H(2)S via the mitochondrial sulfide oxidation pathway. We have recently shown that at high sulfide concentrations, ferric...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Vitvitsky, Victor, Yadav, Pramod K., An, Sojin, Seravalli, Javier, Cho, Uhn-Soo, Banerjee, Ruma
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392699/
https://ncbi.nlm.nih.gov/pubmed/28213526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.774943
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