Preclinical toxicity screening of intrathecal oxytocin in rats and dogs

BACKGROUND: Anatomic, physiologic, and behavioral studies in animals suggest that spinally released oxytocin should produce analgesia in humans and may also protect from chronic pain after injury. Here we report preclinical toxicity screening of oxytocin for intrathecal delivery. METHODS: Intratheca...

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Pubblicato in:Anesthesiology
Autori principali: Yaksh, Tony L., Hobo, Shotaro, Peters, Christopher, Osborn, Kent G., Richter, Philip J., Rossi, Steven S., Grafe, Marjorie R., Eisenach, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392224/
https://ncbi.nlm.nih.gov/pubmed/24492326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000148
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