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Evaluation of spinal toxicity and long-term spinal reflex function following intrathecal levobupivacaine in the neonatal rat

BACKGROUND: Neuraxial anesthesia is utilized in children of all ages. Local anesthetics produce dose-dependent toxicity in certain adult models, but the developing spinal cord may also be susceptible to drug-induced apoptosis. In postnatal rodents, we examined effects of intrathecal levobupivacaine...

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Autors principals: Hamurtekin, Emre, Fitzsimmons, Bethany L., Shubayev, Veronica I., Grafe, Marjorie R., Deumens, Ronald, Yaksh, Tony L., Walker, Suellen M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732172/
https://ncbi.nlm.nih.gov/pubmed/23514721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31828fc7e7
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