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The Effects of Intrathecal and Systemic Gabapentin on Spinal Substance P Release
BACKGROUND: Gabapentin binds at the extracellular α2δ1 subunit of voltage sensitive calcium channels. Some voltage sensitive calcium channels regulate substance P release from small primary afferents. We sought to determine in vivo if spinal and/or systemic gabapentin at antihyperalgesic doses will...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347974/ https://ncbi.nlm.nih.gov/pubmed/21385982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e31820f2a16 |
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