Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus

The emergence of the novel influenza A virus (IAV) H7N9 since 2013 has caused concerns about the ability of the virus to spread between humans. Analysis of the receptor-binding properties of the H7 protein of a human isolate revealed modestly increased binding to α2,6 sialosides and reduced, but sti...

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Bibliographic Details
Published in:J Virol
Main Authors: Dai, Meiling, McBride, Ryan, Dortmans, Jos C. F. M., Peng, Wenjie, Bakkers, Mark J. G., de Groot, Raoul J., van Kuppeveld, Frank J. M., Paulson, James C., de Vries, Erik, de Haan, Cornelis A. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391454/
https://ncbi.nlm.nih.gov/pubmed/28202753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00049-17
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