Evolution of the Hemagglutinin Protein of the New Pandemic H1N1 Influenza Virus: Maintaining Optimal Receptor Binding by Compensatory Substitutions

Pandemic influenza A H1N1 (pH1N1) virus emerged in 2009. In the subsequent 4 years, it acquired several genetic changes in its hemagglutinin (HA). Mutations may be expected while virus is adapting to the human host or upon evasion from adaptive immune responses. However, pH1N1 has not displayed any...

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Detalhes bibliográficos
Main Authors: de Vries, Robert P., de Vries, Erik, Martínez-Romero, Carles, McBride, Ryan, van Kuppeveld, Frank J., Rottier, Peter J. M., García-Sastre, Adolfo, Paulson, James C., de Haan, Cornelis A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838262/
https://ncbi.nlm.nih.gov/pubmed/24109242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01955-13
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