The 2(nd) sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance

Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. NAs of avian, but not human viruses, contain a functional 2(nd) sialic acid (SIA)-binding site (2S...

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Udgivet i:PLoS Pathog
Main Authors: Du, Wenjuan, Guo, Hongbo, Nijman, Vera S., Doedt, Jennifer, van der Vries, Erhard, van der Lee, Joline, Li, Zeshi, Boons, Geert-Jan, van Kuppeveld, Frank J. M., de Vries, Erik, Matrosovich, Mikhail, de Haan, Cornelis A. M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586374/
https://ncbi.nlm.nih.gov/pubmed/31181126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007860
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