Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry

The nonhomologous end-joining (NHEJ) pathway is the primary repair pathway for DNA double strand breaks (DSBs) in humans. Repair is mediated by a core complex of NHEJ factors that includes a ligase (DNA Ligase IV; L4) that relies on juxtaposition of 3΄ hydroxyl and 5΄ phosphate termini of the strand...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Reid, Dylan A., Conlin, Michael P., Yin, Yandong, Chang, Howard H., Watanabe, Go, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389564/
https://ncbi.nlm.nih.gov/pubmed/27924007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1221
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