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Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
The nonhomologous end-joining (NHEJ) pathway is the primary repair pathway for DNA double strand breaks (DSBs) in humans. Repair is mediated by a core complex of NHEJ factors that includes a ligase (DNA Ligase IV; L4) that relies on juxtaposition of 3΄ hydroxyl and 5΄ phosphate termini of the strand...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389564/ https://ncbi.nlm.nih.gov/pubmed/27924007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1221 |
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