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CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells

Gene editing techniques have been extensively used to attempt to model recurrent genomic rearrangements found in tumor cells. These methods involve the induction of double-strand breaks at endogenous loci followed by the identification of breakpoint junctions within a population, which typically ari...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Vanoli, Fabio, Tomishima, Mark, Feng, Weiran, Lamribet, Khadija, Babin, Loelia, Brunet, Erika, Jasin, Maria
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389291/
https://ncbi.nlm.nih.gov/pubmed/28325870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700622114
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