CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells

Gene editing techniques have been extensively used to attempt to model recurrent genomic rearrangements found in tumor cells. These methods involve the induction of double-strand breaks at endogenous loci followed by the identification of breakpoint junctions within a population, which typically ari...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Vanoli, Fabio, Tomishima, Mark, Feng, Weiran, Lamribet, Khadija, Babin, Loelia, Brunet, Erika, Jasin, Maria
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389291/
https://ncbi.nlm.nih.gov/pubmed/28325870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700622114
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