Modified mRNA vaccines protect against Zika virus infection

The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Richner, Justin M., Himansu, Sunny, Dowd, Kimberly A., Butler, Scott, Salazar, Vanessa, Fox, Julie M., Julander, Justin G., Tang, William W., Shresta, Sujan, Pierson, Theodore C., Ciaramella, Giuseppe, Diamond, Michael S.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388441/
https://ncbi.nlm.nih.gov/pubmed/28222903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.017
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