Modified mRNA vaccines protect against Zika virus infection

The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Richner, Justin M., Himansu, Sunny, Dowd, Kimberly A., Butler, Scott, Salazar, Vanessa, Fox, Julie M., Julander, Justin G., Tang, William W., Shresta, Sujan, Pierson, Theodore C., Ciaramella, Giuseppe, Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388441/
https://ncbi.nlm.nih.gov/pubmed/28222903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.017
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