Kynurenine Pathway Activation in Human African Trypanosomiasis

BACKGROUND. The kynurenine pathway of tryptophan oxidation is associated with central nervous system (CNS) inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of human African trypanosomiasis (HAT). In this study, we...

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Pubblicato in:J Infect Dis
Autori principali: Sternberg, Jeremy M., Forrest, Caroline M., Dalton, R. Neil, Turner, Charles, Rodgers, Jean, Stone, Trevor W., Kennedy, Peter G. E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Major Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388295/
https://ncbi.nlm.nih.gov/pubmed/28013248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw623
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