Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2(+/−) mice, using liquid chromatography-tandem mass spectrometry

To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography – tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy. There were...

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Detalhes bibliográficos
Publicado no:Neurochem Int
Main Authors: Forrest, Caroline M., Kennedy, Peter G.E., Rodgers, Jean, Dalton, R. Neil, Turner, Charles, Darlington, L. Gail, Cobb, Stuart R., Stone, Trevor W.
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115650/
https://ncbi.nlm.nih.gov/pubmed/27623092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2016.09.012
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