Absence of physiological Ca(2+) transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

BACKGROUND: Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production...

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Vydáno v:Skelet Muscle
Hlavní autoři: Karam, Chehade, Yi, Jianxun, Xiao, Yajuan, Dhakal, Kamal, Zhang, Lin, Li, Xuejun, Manno, Carlo, Xu, Jiejia, Li, Kaitao, Cheng, Heping, Ma, Jianjie, Zhou, Jingsong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387329/
https://ncbi.nlm.nih.gov/pubmed/28395670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0123-0
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