Absence of physiological Ca(2+) transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

BACKGROUND: Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production...

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Veröffentlicht in:Skelet Muscle
Hauptverfasser: Karam, Chehade, Yi, Jianxun, Xiao, Yajuan, Dhakal, Kamal, Zhang, Lin, Li, Xuejun, Manno, Carlo, Xu, Jiejia, Li, Kaitao, Cheng, Heping, Ma, Jianjie, Zhou, Jingsong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387329/
https://ncbi.nlm.nih.gov/pubmed/28395670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0123-0
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