Comparative Efficacy and Immunogenicity of Replication-Defective, Recombinant Glycoprotein, and DNA Vaccines for Herpes Simplex Virus 2 Infections in Mice and Guinea Pigs

Many candidate vaccines are effective in animal models of genital herpes simplex virus type 2 (HSV-2) infection. Among them, clinical trials showed moderate protection from genital disease with recombinant HSV-2 glycoprotein D (gD2) in alum-monophosphoryl lipid A adjuvant only in HSV women seronegat...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Hoshino, Yo, Dalai, Sarat K., Wang, Kening, Pesnicak, Lesley, Lau, Tsz Y., Knipe, David M., Cohen, Jeffrey I., Straus, Stephen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2005
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538700/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15596834/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.1.410-418.2005
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