Construction, Phenotypic Analysis, and Immunogenicity of a UL5/UL29 Double Deletion Mutant of Herpes Simplex Virus 2

A number of studies have shown that replication-defective mutant strains of herpes simplex virus (HSV) can induce protective immunity in animal systems against wild-type HSV challenge. However, all of those studies used viruses with single mutations. Because multiple, stable mutations provide optima...

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Bibliografiska uppgifter
Huvudupphovsmän: Da Costa, Xavier, Kramer, Martha F., Zhu, Jia, Brockman, Mark A., Knipe, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Vaccines and Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC112327/
https://ncbi.nlm.nih.gov/pubmed/10933704
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