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Live Attenuated Herpes Simplex Virus 2 Glycoprotein E Deletion Mutant as a Vaccine Candidate Defective in Neuronal Spread

A herpes simplex virus 2 (HSV-2) glycoprotein E deletion mutant (gE2-del virus) was evaluated as a replication-competent, attenuated live virus vaccine candidate. The gE2-del virus is defective in epithelial cell-to-axon spread and in anterograde transport from the neuron cell body to the axon termi...

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Bibliografski detalji
Glavni autori: Awasthi, Sita, Zumbrun, Elizabeth E., Si, Huaxin, Wang, Fushan, Shaw, Carolyn E., Cai, Michael, Lubinski, John M., Barrett, Shana M., Balliet, John W., Flynn, Jessica A., Casimiro, Danilo R., Bryan, Janine T., Friedman, Harvey M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318599/
https://ncbi.nlm.nih.gov/pubmed/22318147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07203-11
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