Immunization with a Vaccine Combining Herpes Simplex Virus 2 (HSV-2) Glycoprotein C (gC) and gD Subunits Improves the Protection of Dorsal Root Ganglia in Mice and Reduces the Frequency of Recurrent Vaginal Shedding of HSV-2 DNA in Guinea Pigs Compared to Immunization with gD Alone

Attempts to develop a vaccine to prevent genital herpes simplex virus 2 (HSV-2) disease have been only marginally successful, suggesting that novel strategies are needed. Immunization with HSV-2 glycoprotein C (gC-2) and gD-2 was evaluated in mice and guinea pigs to determine whether adding gC-2 to...

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Hauptverfasser: Awasthi, Sita, Lubinski, John M., Shaw, Carolyn E., Barrett, Shana M., Cai, Michael, Wang, Fushan, Betts, Michael, Kingsley, Susan, DiStefano, Daniel J., Balliet, John W., Flynn, Jessica A., Casimiro, Danilo R., Bryan, Janine T., Friedman, Harvey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187515/
https://ncbi.nlm.nih.gov/pubmed/21813597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00849-11
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