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Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccine

Herpes simplex virus type 1 (HSV-1) glycoprotein C (gC-1) binds complement component C3b and inhibits complement-mediated immunity. HSV-1 glycoprotein D (gD-1) is a potent immunogen and a candidate antigen for a subunit vaccine. We evaluated whether combined immunization with gD-1 and gC-1 provides...

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Bibliografiske detaljer
Main Authors: Awasthi, Sita, Lubinski, John M., Friedman, Harvey M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783579/
https://ncbi.nlm.nih.gov/pubmed/19761834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.09.017
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