Live Attenuated Herpes Simplex Virus 2 Glycoprotein E Deletion Mutant as a Vaccine Candidate Defective in Neuronal Spread

A herpes simplex virus 2 (HSV-2) glycoprotein E deletion mutant (gE2-del virus) was evaluated as a replication-competent, attenuated live virus vaccine candidate. The gE2-del virus is defective in epithelial cell-to-axon spread and in anterograde transport from the neuron cell body to the axon termi...

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Hauptverfasser: Awasthi, Sita, Zumbrun, Elizabeth E., Si, Huaxin, Wang, Fushan, Shaw, Carolyn E., Cai, Michael, Lubinski, John M., Barrett, Shana M., Balliet, John W., Flynn, Jessica A., Casimiro, Danilo R., Bryan, Janine T., Friedman, Harvey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318599/
https://ncbi.nlm.nih.gov/pubmed/22318147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07203-11
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