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Herpes Simplex Virus Vectors Elicit Durable Immune Responses in the Presence of Preexisting Host Immunity

Herpes simplex virus (HSV) recombinants are being developed as vaccine vectors for the expression of heterologous antigens. There is concern, however, that preexisting HSV immunity may decrease their effectiveness. We have addressed this issue in an animal model. Immunized mice were inoculated with...

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Autors principals: Brockman, Mark A., Knipe, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136066/
https://ncbi.nlm.nih.gov/pubmed/11907207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.8.3678-3687.2002
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