Comparative Efficacy and Immunogenicity of Replication-Defective, Recombinant Glycoprotein, and DNA Vaccines for Herpes Simplex Virus 2 Infections in Mice and Guinea Pigs

Many candidate vaccines are effective in animal models of genital herpes simplex virus type 2 (HSV-2) infection. Among them, clinical trials showed moderate protection from genital disease with recombinant HSV-2 glycoprotein D (gD2) in alum-monophosphoryl lipid A adjuvant only in HSV women seronegat...

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Autores principales: Hoshino, Yo, Dalai, Sarat K., Wang, Kening, Pesnicak, Lesley, Lau, Tsz Y., Knipe, David M., Cohen, Jeffrey I., Straus, Stephen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC538700/
https://ncbi.nlm.nih.gov/pubmed/15596834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.410-418.2005
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