Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs

A replication-defective HSV-2 vaccine, dl5-29, which is deleted for two essential early genes, UL5 and UL29, is highly immunogenic and protective in mice and guinea pigs. In a prior study, a derivative of HSV-2 dl5-29 termed dl5-29-41L, which has an additional deletion in UL41 (that encodes the viri...

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Autori principali: Hoshino, Yo, Pesnicak, Lesley, Dowdell, Kennichi C., Lacayo, Juan, Dudek, Timothy, Knipe, David M., Straus, Stephen E., Cohen, Jeffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564964/
https://ncbi.nlm.nih.gov/pubmed/18565628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.05.022
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