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Protection from Herpes Simplex Virus (HSV) 2 Infection with Replication-Defective HSV-2 or Glycoprotein D2 Vaccines in HSV-1 Seropositive and Seronegative Guinea Pigs

BACKGROUND: A herpes simplex virus (HSV) 2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1 seronegative women, but not in men or HSV-1 seropositive women. METHODS: To determine the effect of HSV-1 serostatus on eff...

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Detalhes bibliográficos
Main Authors: Hoshino, Yo, Pesnicak, Lesley, Dowdell, Kennichi C., Burbelo, Peter D., Knipe, David M., Straus, Stephen E., Cohen, Jeffrey I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826825/
https://ncbi.nlm.nih.gov/pubmed/19702506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/605645
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