Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer

Cystatin SN (CST1) is a specific inhibitor belonging to the cystatin superfamily that controls the proteolytic activities of cysteine proteases such as cathepsins. Our previous study showed that high CST1 expression enhances tumor metastasis and invasiveness in colorectal cancer. Recently, auranofin...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Oh, Byung Moo, Lee, Seon-Jin, Cho, Hee Jun, Park, Yun Sun, Kim, Jong-Tae, Yoon, Suk Ran, Lee, Sang Chul, Lim, Jong-Seok, Kim, Bo-Yeon, Choe, Yong-Kyung, Lee, Hee Gu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386512/
https://ncbi.nlm.nih.gov/pubmed/28300829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.100
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