Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region

The membrane proximal external region (MPER) of HIV-1 gp41 is targeted by broadly neutralizing antibodies (bnAbs) 4E10 and 10E8. In this proof-of-concept study, we evaluated a novel multi-immunogen vaccine strategy referred to as Incremental, Phased Antigenic Stimulation for Rapid Antibody Maturatio...

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Bibliographic Details
Published in:Virology
Main Authors: Banerjee, Saikat, Shi, Heliang, Banasik, Marisa, Moon, Hojin, Lees, William, Qin, Yali, Harley, Andrew, Shepherd, Adrian, Cho, Michael W.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385849/
https://ncbi.nlm.nih.gov/pubmed/28237764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.02.015
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