Modulating immunogenic properties of HIV-1 gp41 membrane-proximal external region by destabilizing six-helix bundle structure

The C-terminal alpha-helix of gp41 membrane-proximal external region (MPER; (671)NWFDITNWLWYIK(683)) encompassing 4E10/10E8 epitopes is an attractive target for HIV-1 vaccine development. We previously reported that gp41-HR1-54Q, a trimeric protein comprised of the MPER in the context of a stable si...

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發表在:Virology
Main Authors: Banerjee, Saikat, Shi, Heliang, Habte, Habtom H., Qin, Yali, Cho, Michael W.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896743/
https://ncbi.nlm.nih.gov/pubmed/26803471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.01.002
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