Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk

Macrophage-inducible C-type lectin (Mincle) interacts with the γ-subunit of high-affinity IgE receptor (FcεRIγ) and activates Syk by recognizing its specific ligand, trehalose-6,6′-dimycolate, a glycolipid produced by Mycobacterium tuberculosis. It has been suggested that mast cells participate in t...

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Publicado no:Sci Rep
Main Authors: Honjoh, Chisato, Chihara, Kazuyasu, Yoshiki, Hatsumi, Yamauchi, Shota, Takeuchi, Kenji, Kato, Yuji, Hida, Yukio, Ishizuka, Tamotsu, Sada, Kiyonao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385489/
https://ncbi.nlm.nih.gov/pubmed/28393919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46064
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