Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcεRI-activated RBL-2H3 basophilic cells

Spleen tyrosine kinase (Syk) binds ITAM-bearing receptors in a wide variety of cell types. One such example is the activation of mast cells, basophils and eosinophils via the stimulation of the FcεRI receptor by IgE/allergen complexes. The possible role of Syk in inflammatory signaling cascades has...

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Udgivet i:Cell Immunol
Main Authors: Sanderson, Michael P., Gelling, Stephen J., Rippmann, Jörg F., Schnapp, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124319/
https://ncbi.nlm.nih.gov/pubmed/20053395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2009.12.004
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