Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Spleen Tyrosine Kinase (Syk) in Rat Mast Cells

Dectin-1 recognizes β-glucan and plays important roles for the antifungal immunity through the activation of spleen tyrosine kinase (Syk) in dendritic cells or macrophages. Recently, expression of Dectin-1 was also identified in human and mouse mast cells, although its physiological roles were large...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kimura, Yukihiro, Chihara, Kazuyasu, Honjoh, Chisato, Takeuchi, Kenji, Yamauchi, Shota, Yoshiki, Hatsumi, Fujieda, Shigeharu, Sada, Kiyonao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223353/
https://ncbi.nlm.nih.gov/pubmed/25246527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581322
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