Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues

Human immunodeficiency virus type I (HIV-1) reverse transcriptase (RT) resistance mutations reduce the susceptibility of the virus to nucleoside analogues but may also impair viral DNA synthesis. To further characterize the effect of nucleoside analogue resistance mutations on the efficiency and kin...

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Bibliographic Details
Main Authors: Bouchonnet, Francine, Dam, Elisabeth, Mammano, Fabrizio, de Soultrait, Vaea, Henneré, Gaëlle, Benech, Henri, Clavel, François, Hance, Allan J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC538537/
https://ncbi.nlm.nih.gov/pubmed/15613309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.2.812-822.2005
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